Vibrio vulnificus: disease and pathogenesis.
نویسندگان
چکیده
6 Melissa K. Jones and James D. Oliver 1 7 8 Department of Biology 9 10 University of North Carolina at Charlotte 11 12 Charlotte, NC 28223 13 14 15 16 17 18 19 20 21 22 1 To whom correspondence should be addressed 23 email: [email protected] 24 tel: 704-687-8516 25 fax: 206-350-1385 26 Copyright © 2009, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. Infect. Immun. doi:10.1128/IAI.01046-08 IAI Accepts, published online ahead of print on 2 March 2009
منابع مشابه
Molecular Pathogenesis of Vibrio vulnificus.
Vibrio vulnificus is an opportunistic pathogen of humans that has the capability of causing rare, yet devastating disease. The bacteria are naturally present in estuarine environments and frequently contaminate seafoods. Within days of consuming uncooked, contaminated seafood, predisposed individuals can succumb to sepsis. Additionally, in otherwise healthy people, V. vulnificus causes wound in...
متن کاملEvidence that AphB, essential for the virulence of Vibrio vulnificus, is a global regulator.
The Vibrio vulnificus aphB mutant was significantly less virulent than the wild type and was impaired in motility and adherence to host cells. Microarray analysis revealed that AphB of V. vulnificus (AphB(Vv)) influences the expression of over 10% of the V. vulnificus genome. The combined results indicated that AphB(Vv) is a global regulator contributing to the pathogenesis of V. vulnificus.
متن کاملHigh growing ability of Vibrio vulnificus biotype 1 is essential for production of a toxic metalloprotease causing systemic diseases in humans.
Vibrio vulnificus biotype 1, a causative agent of fatal septicemia or wound infection in humans, is known to produce a toxic metalloprotease as an important virulence determinant. V. vulnificus biotype 2 (serovar E), a primary eel pathogen, was found to elaborate an extracellular metalloprotease that was indistinguishable from that of biotype 1. The potential of V. vulnificus biotype 1 for prod...
متن کاملCharacterization of a Vibrio vulnificus LysR homologue, HupR, which regulates expression of the haem uptake outer membrane protein, HupA.
In Vibrio vulnificus, the ability to acquire iron from the host has been shown to correlate with virulence. Here, we show that the DNA upstream of hupA (haem uptake receptor) in V. vulnificus encodes a protein in the inverse orientation to hupA (named hupR). HupR shares homology with the LysR family of positive transcriptional activators. A hupA-lacZ fusion contained on a plasmid was transforme...
متن کاملVibrio vulnificus: From Oyster Colonist to Human Pathogen
Introduction Vibrio vulnificus is a Gram-negative halophilic bacterium commonly found in warm coastal waters. The bacterium can cause severe gastroenteritis from consumption of raw seafood as well as wound infections and necrotizing fasciitis, with mortality rates for sepsis and wound infection at 50% and 17%, respectively [1]. Although infections are rare, V. vulnificus is responsible for the ...
متن کاملComplete genome sequence of Vibrio vulnificus FORC_017 isolated from a patient with a hemorrhagic rash after consuming raw dotted gizzard shad
BACKGROUND Vibrio vulnificus, a resident in the human gut, is frequently found in seafood, causing food-borne illnesses including gastroenteritis and severe septicemia. While V. vulnificus has been known to be one of the major food-borne pathogens, pathogenicity and virulence factors are not fully understood yet. To extend our understanding of the pathogenesis of V. vulnificus at the genomic le...
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عنوان ژورنال:
- Infection and immunity
دوره 77 5 شماره
صفحات -
تاریخ انتشار 2009